DERMATOLOGY AND SKIN CARE

5-ALA 5-Amino Levulenic Acid
  • Prescription Only
Bleach and Fade Gel
  • Prescription Only
Clobetasol Cream
  • Prescription Only
Collagen Cream
  • Prescription Only
Estradiol Cream
  • Prescription Only
Estriol Cream
  • Prescription Only

ESTROGEN CREAMS

The coincidence of climacteric symptoms and the beginning of skin aging is directly associated with estrogen deficiency. As we age into menopause the estrogen levels begin to fall with the subsequent aging and lining of the skin. By application of refined estrogens (either estriol perimenopausally or estradiol menopausally) this process may be reversed by use of this therapy.

Available on prescription only

ESTROGENS AND THEIR USE AS FACIAL CREAMS

A dermatological cream has three primary functions :

  • To protect the skin from the environment and permit skin rejuvenation
  • To provide for skin an emollient or hydration effect
  • To provide a means of conveying medication to the skin for a specific effect either systemically or, as in this case, locally.

The cream is elegant, nonallergic, nonsensetising, low-irritant and stable.

SKIN AGEING

The coincidence of climacteric symptoms and the beginning of skin ageing suggests that estrogen deficiency may be a common and important factor in both the peri- and menopausal woman. Often hormones have been considered important in endogenous ageing of skin. Thus by using topical application of estrogens this ageing may be reversed eg by either estradiol 0.01% cream for the menopausal and postmenopausal woman, or estriol 0.3% cream for the premenopausal woman- available only on prescription. From research we have found that elasticity and firmness was markedly improved after a period of six months, and wrinkle depth and pore size had decreased by 61-100%. Furthermore, skin moisture, type III collagen and the number of collagen fibres all improved dramatically. With all these external benefits no systemic absorption was found, and thus no estrogenic side effects occurred. From studies done it has been found that at the and of a six month clinical trial, marked improvement of skin ageing symptoms was noted;

  • Clinical improvement of specific skin parameters was evaluated and was seen in 9-19 weeks with estradiol and 7-17 weeks with estriol.
  • Improvement in skin elasticity and firmness was noted after 13 weeks with estradiol and 11 weeks with estriol.
  • Improvement in skin moisture was noted after 9 weeks with estradiol and 8 weeks with estriol.
  • Improvement in wrinkle depth was noted after 16 weeks with estradiol and 17 weeks with estriol.
  • Reduction of pore size was noted after 19 weeks with estradiol and 16 weeks with estriol.

All the above improvements appeared in 61–100% of cases.

In more detail wrinkle depth reduction was significant with estradiol and highly significant with estriol. Side effects were more pronounced with the estradiol group than the estriol group.

Both estradiol and estriol exhibited significant effect on increasing collagen fibre and striking increases in collagen III. This is why skin was firmed and wrinkles reduced. Type I collagen is predominantly in adult skin while type III is although distributed about the body is predominant in fetuses.

The positive effect of the estrogens on hydration was noted in all patients. This may be due to the increase in skin thickness with subsequently elevated amounts of natural moisturising factor.

CONCLUDING

By considering the results of topical estrogen treatment in skin ageing in women, a better insight can be gained as to the hormonal aspects of endogenous ageing of the skin. Various structures involved in skin ageing are under hormonal control. If decreased estrogen levels contribute to decreased functions of the skin, local estrogen treatment of the skin would in turn represent a local hormone substitution therapy of the skin. So far, estrogen compounds and, in particular estriol represent a new and promising therapeutic approach towards skin ageing in peri and menopausal women.